2-Phenylethanaminium chloride
β-Phenylethylamine hydrochloride
CAS: 156-28-5
Molecular Formula: C8H12ClN
2-Phenylethanaminium chloride - Names and Identifiers
| Name | β-Phenylethylamine hydrochloride |
| Synonyms | B-PHENYLETHYLAMINE HCL beta-PhenethylamineHCl 2-Phenylethanaminium chloride 2-Phenethylamine hydrochloride Benzeneethanamino hydrochloride 2-Phenylethylamine hydrochloride β-Phenylethylamine hydrochloride B-PHENYLETHYLAMINE HYDROCHLORIDE .beta.-Phenethylamine hydrochloride 1-Phenyl-2-aminoethane hydrochloride 1-Amino-2-phenylethane hydrochloride .beta.-Phenylethylamine hydrochloride |
| CAS | 156-28-5 |
| EINECS | 205-849-2 |
| InChI | InChI=1/C8H11N.ClH/c9-7-6-8-4-2-1-3-5-8;/h1-5H,6-7,9H2;1H |
| InChIKey | SKHIBNDAFWIOPB-UHFFFAOYSA-N |
2-Phenylethanaminium chloride - Physico-chemical Properties
| Molecular Formula | C8H12ClN |
| Molar Mass | 157.64 |
| Melting Point | 220-222°C(lit.) |
| Boling Point | 217 °C |
| Flash Point | 81 °C |
| Vapor Presure | 0.398mmHg at 25°C |
| Appearance | Powder or Crystalline Powder |
| Color | White to off-white |
| Merck | 14,6026 |
| BRN | 3624163 |
| In vitro study | 2-Phenylethanamine (PEA) is soluble in water, ethanol, and ether. Phenethylamine is a skin irritant and possible sensitizer. 2-Phenylethanamine is believed to function as a neuromodulator or neurotransmitter (a trace amine). It is also found in many foods such as chocolate, especially after microbial fermentation. 2-Phenylethanamine is a precursor to the neurotransmitter phenylethanolamine. High levels of 2-Phenylethanamine have been found in the urine of schizophrenics but it is not significantly elevated in the serum or CSF of schizophrenics. Urinary levels of 2-Phenylethanamine are significantly lower in children with attention deficit hyperactivity disorder. 2-Phenylethanamine is useful for scaring off rodent pests. |
2-Phenylethanaminium chloride - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | SH7175000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | eye-man 50 mg SEV AIMDAP 39,404,27 |
2-Phenylethanaminium chloride - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | 2-phenylethylamine hydrochloride is a primary amine compound. 2-phenylethylamine hydrochloride is a kind of important chemical raw materials, which has a wide range of applications in the field of chemical industry (especially fine chemical and pharmaceutical industry). |
| preparation | (1) imidization: 3, 4-diphenylfuran-2, 5-dione (100.0mg,0.4mmol) and 1% ammonia (3.4g, 2.0mmol) were added to a 10ml microwave reaction tube, and the power of the microwave reactor was set at 80W, microwave irradiation at 120 ° C. Should be 5 minutes; After cooling, using 20ml of ethyl acetate extraction twice, combined organic layer, adding anhydrous sodium sulfate to dry, the solvent ethyl acetate was recovered under reduced pressure to give 3, 4-diphenyl-1h-pyrrol-2, 5-dione in a yield of 100%, which was directly used for the subsequent N-alkylation reaction. (2)N-alkylation: β-bromophenylethane (73.6mg,0.4mmol) was added to give 1-phenylethyl-3, 4-diphenyl- 1H-pyrrol-2, 5-dione. (3) Hydrolysis: The above 1-phenethyl-3, 4-diphenyl-1h-pyrrol-2, 5-dione is hydrolyzed to obtain raw material 3, 4-diphenylfuran-2, 5-dione (97.6mg), recovery 98%; 2-phenylethylamine hydrochloride (56.6mg), yield 90%. (Based on the raw material β-bromostyrene ethane). |
| biological activity | 2-Phenylethanamine hydrochloride is considered a neuromodulator or neurotransmitter. |
Last Update：2024-04-09 02:00:04
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